Optical multiplexed bioassays on photonic crystals for breast cancer biomarker detection

An optical biosensor for proteomic breast cancer biomarker detection in complex media is presented. Bloch Surface Waves (BSW) excited onto one dimensional photonic crystal (1DPC) were used to probe the interaction of HER2 with three antibody species and an inert protein (Bovine Serum Albumin - BSA). The system combines Label-Free readings track bioassay real-time development Fluorescence emission quantification evaluate level specific between antigen antibodies. results confirm a distinguishable affinity antibodies analyte according their specificity even at low surface density (about 1173 pg/mm 2 ).